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Ed Ruscha Safe and Effective Medication For Sale

Ed Ruscha
Ed Ruscha - Safe and Effective Medication, 2011, Lithograph in colors on Somerset Satin paper

Safe and Effective Medication, 2011

Lithograph in colors on Somerset Satin paper

35 x 35 in 88.9 x 88.9 cm

Edition

Edition of 20

About this work

This lithograph presents Ruscha's characteristically bold text-based composition against a gradient background that transitions from deep blue at the top to warm orange at the bottom. The phrase "SAFE AND EFFECTIVE MEDICATION" appears in capital letters, rendered in the artist's signature sans-serif typeface. The letters seem to float across the chromatic shift, creating a striking visual tension between the clinical authority of the pharmaceutical language and the atmospheric, almost cinematic quality of the colored field. The lithographic technique achieves remarkable depth and luminosity in the color transitions. Created during a period when Ruscha continued to explore language as both image and concept, this work exemplifies his decades-long investigation into American vernacular and the ambiguous messages embedded in everyday phrases. The unsettling juxtaposition of reassuring pharmaceutical terminology with an almost unsettling color palette invites multiple interpretations about trust, commerce, and contemporary life. This piece represents an important example of Ruscha's mature work in printmaking, a medium he has elevated throughout his distinguished career. Available for purchase — enquire for price and availability.

Price on Application

Auction History

Ed Ruscha - Safe and Effective Medication

Safe and Effective Medication · Ed Ruscha · Sotheby's · 2008-05 · $10,625

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Safe and Effective Medication

About Ed Ruscha

Ed Ruscha (b. 1937, Omaha, Nebraska) is one of the most significant and enduring figures in American art, a defining voice of the West Coast avant-garde whose influence reaches from Pop Art and Conceptualism through to contemporary painting and photography. Raised in Oklahoma City, Ruscha moved to Los Angeles in 1956 to study at the Chouinard Art Institute — later reborn as CalArts — and never left, making the city's peculiar light, architecture, and vernacular culture the permanent subject matter of his art. Where New York's Pop artists turned to consumer packaging and celebrity, Ruscha turned to the American road: the gas station, the parking lot, the Strip, the Hollywood sign, the word itself rendered monumental against desert sky.

Ruscha's practice resists easy categorisation. He emerged in the early 1960s simultaneously as a painter, photographer, printmaker, and book artist, and has never relinquished any of these disciplines. His word paintings — single terms or deadpan phrases set against vast Californian landscapes in impossibly smooth, commercial-feeling typefaces — are among the most immediately recognisable works in postwar American art. The words float in those expanses like hallucinations, stripped of narrative but dense with implication: Hollywood, OOF, Annie, Brave Men Run in My Family. Alongside the paintings, Ruscha produced a series of artist books beginning in 1963 with Twentysix Gasoline Stations, followed by Every Building on the Sunset Strip (1966), Thirtyfour Parking Lots (1967), Nine Swimming Pools and a Broken Glass (1968), and others — works that are now regarded as foundational to both the history of Conceptual Art and the modern artist book. Shot in a flat, documentary style with no compositional drama, they transformed the photographically ordinary into something philosophically charged.

His print and edition output is among the most substantial and actively traded of any American artist of his generation. Working across screenprint, aquatint, lithograph, etching, and photogravure, Ruscha produced major print series throughout his career: the Standard Station screenprints, Hollywood, Mountain Series, Book Covers, Bow-Tie Landscapes, various word and phrase prints. The breadth of this body of work allows collectors to engage meaningfully with his practice at a wide range of price points, from modest works on paper to landmark edition prints that have achieved significant results at the major auction houses. His auction record was set in November 2024 when Standard Station, Ten-Cent Western Being Torn in Half achieved $68,260,000 at Christie's — a figure that confirms his standing among the top tier of American postwar artists.

Ruscha represented the United States at the Venice Biennale in 2005, a singular honour that reflected his international standing. His work is held in permanent collections at the Museum of Modern Art, the Whitney Museum of American Art, the Metropolitan Museum of Art, LACMA, SFMOMA, Tate Modern, the Centre Pompidou, and over a hundred other institutions worldwide. The range and consistency of his output — spanning more than six decades without a diminution of inventiveness — makes him one of the few artists of the 1960s generation whose market and critical reputation has only deepened with time.

Guy Hepner brings deep expertise to the Ed Ruscha print and edition market, with inventory spanning all of his major series and a thorough understanding of condition, provenance, and relative rarity across his print output. Our gallery at 177 Tenth Avenue, New York offers collectors authentic Ruscha works with expert guidance on acquisition and valuation. For those looking to sell or appraise Ruscha prints and editions, we provide free, confidential valuations and connections to a global network of serious collectors.

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